Saturday, October 24, 2009

Is diabetic neuropathy solely due to microvascular complications?

Can't non-enzymatic glycosilation of the nervous tissue play a role?
in my answer to your previous Q about diabetes you have the answer for this one 2
Glycosylation will help the body fix the problem or any other type of cellular disfunction.
Have you read the information on my page?
The causes are probably different for different varieties of diabetic neuropathy. Researchers are studying the effect of glucose on nerves to find out exactly how prolonged exposure to high glucose causes neuropathy. Nerve damage is likely due to a combination of factors:metabolic factors, such as high blood glucose, long duration of diabetes, possibly low levels of insulin, and abnormal blood fat levels
neurovascular factors, leading to damage to the blood vessels that carry oxygen and nutrients to the nerves
autoimmune factors that cause inflammation in nerves
mechanical injury to nerves, such as carpal tunnel syndrome
inherited traits that increase susceptibility to nerve disease
lifestyle factors such as smoking or alcohol use

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